Toggle navigation

#multiphoton53 POSTS

Post Content
The image shows multiphoton microscopy of an unstained mouse skin section acquired using the 4Tune detector. Leica Microsystems’ 4Tune detector, the key component of the SP8 DIVE Deep In Vivo Explorer, provides spectrally tunable image recording with non-descanning detection. An innovative solution for multiparameter multiphoton microscopy.
The green color codes for autofluorescence of muscle tissue. Red shows second harmonic generation of fibers upon illumination with 900 nm. The blue pattern is generated by third harmonic generation at lipid boundaries from illumination at 1230 nm.
.
#autofluorescence #research #multiphoton #multiphotonmicroscopy #confocal #confocalmicroscopy #microscopy #science #microscope #scienceiscool #scienceisbeautiful #scienceisart #scienceisawesome #imageoftheday #leicamicrosystems #leica #pictureoftheday #fromeyetoinsight
It’s not a pointillist image, though it looks like zooming into a masterpiece of art. In it we see the cells of a mouse colon tumor. Many colors mark different parts of tumor cells to show functional distributions. The color gray indicates the origin of the cellular structure from supporting collagen. To reveal important information and to gain insight about the how and why of the tumor, an easy to adjust, fast, and outstandingly sensitive instrument is mandatory. Until now, you always had to painfully find and install filters in your system, hoping that enough light passes through them for each of the colors. However, today, you set all necessary colors with a straight-forward operating user interface. Innovation from Leica Microsystems! This image was recorded with the new Leica multi-photon (MP), multi-color imaging system SP8 DIVE. Whatever dyes, whatever fluorophores your samples express – difficult MP imaging is now as easy as true spectral imaging.
.
The gray color codes for the SHG signal from collagen 1. Lineage traced tumor cells are shown in magenta, blue, green, yellow and red. All channels were recorded with two-photon excitation. Sample and image were kindly provided by J. van Rheenen, H. Snippert, University of Utrecht (the Netherlands) and I. Steinmetz, Leica Microsystems Mannheim.
.
#confocal #dive #deepimaging #multiphoton #mouse #confetti #colorful #multicolor #leica #lifescience #imaging #science #microscope #scienceiscool #scienceisbeautiful #scienceisart #scienceisawesome #nature #fromeyetoinsight #artscience #biology #imageoftheday #leicamicrosystems #pictureoftheday
False coloured SHG image of Intervertebral disc fibres 😍No filter needed on this one!!
#spineresearch #biophysics #microscopy #multiphoton #phd #intervertebraldisc #scienceisart
Hunting Blood Vessels ⭕️ It's been a great day in the lab today, visualising capillaries in the cartilage just before the intervertebral disc 👩🏻‍🔬Some days make all the stress worthwhile!
#geek #geekingout #microcirculation #exeteruni #phd #multiphoton #microscopy #biophysics #spineresearch
Meet the Leica team at the Focus on Microscopy 2017 (FOM), 9 to 12 April 2017, in Bordeaux, France. Get an exclusive first look at a new generation of Leica scientific instruments. Highlight being the SP8 DIVE, the world's first spectrally tunable solution for multi-color multiphoton (MP) imaging. #fom #fom2017 #bordeaux #dive #dmi8 #confocal #dls #lightsheet #nanoscopy #sted #biology #deepimaging #multiphoton #leica #team #lifescience #imaging #science #microscope #scienceiscool #scienceisbeautiful #scienceisart #scienceisawesome #nature #fromeyetoinsight #artscience #biology #leicamicrosystems
Multicolor image of a Confetti Mouse recorded with the new SP8 DIVE with the 4Tune spectral detector. The adaptation to the transgenic markers allows to achieve more contrast and depth for multi-color in vivo deep imaging. SP8 DIVE is the world's first tunable deep imaging solution. The new groundbreaking 4Tune technology allows to adapt the instrument to any transgenic marker in a few seconds and achieve an unmatched quality for deep imaging. This allows to capture up to 67% more of the fluorescence signal. Sample courtesy of Jacco van Rheenen. University of Utrecht, NL
http://ow.ly/XpoJ30aFBt2
.
#confocal #dive #deepimaging #multiphoton #mouse #confetti #colorful #multicolor #leica #lifescience #imaging #science #microscope #scienceiscool #scienceisbeautiful #scienceisart #scienceisawesome #nature #fromeyetoinsight #artscience #biology #imageoftheday #leicamicrosystems #pictureoftheday
#Brain of 7-week old YFP-H #mouse, fixed and cleared with Scale clearing technique. #Multiphoton #microscopy with #ZEISS LSM 780 NLO system with LD Plan-APOCHROMAT 20x/1.0
Hama et al, Nat Neurosci. 2011. #microscope #carlzeiss
March is #ColonCancerAwareness month! Mice are commonly used in scientific research to study the onset and progression of colorectal cancer, as well as to help us understand the physiological events that contribute to the development and spread of the disease.

Credit: Paul Appleton
#olympus #sciart #multiphoton #microscope #micro #microscopic #microscopes #animal #science #research #optics #imaging #objective #mouse #largeintestine #colon #photooftheday #photomicrograph #🔬 #🐭
Launching InSight X3: 3rd Generation Broadly-Tunable #Ultrafast #Laser for #Multiphoton Imaging @PhotonicsWest #BIOS ow.ly/Q91P308nZv6
Scientists characterize molecular signatures of 228 primary cervical cancers and identify SHKBP1, ERBB3, CASP8, HLA-A, and TGFBR2 as novel significantly mutated genes. Shown is a multiphoton fluorescence image of cervical cancer HeLa cells with cytoskeletal microtubules (magenta) and DNA (cyan). The Cancer Genome Atlas Research Network. Nature 2017. Credit: National Center for Microscopy and Imaging Research.

Link to today's paper on meta.com

#cancer #cancers #cervicalcancer #genes #genetics #multiphoton #cancercells #sciencedaily #metasciencedaily #science #sciences #metascienceimageoftheday
Microscopy that goes right under the skin – literally! This sample of a skin epidermis section was acquired with Multiphoton technology. Sample courtesy of Dr. Sonja Wessel, Beiersdorf AB, Hamburg, Germany. Learn more about Multiphoton: http://bit.ly/2hMLYyY. #fromeyetoinsight #microscopy #imaging #resolution #multicolor #confocal #multiphoton #microscope #microscopy #skin #epidermis #picture #research #science #scienceiscool #biology #beautiful #nature #light #leica #leicamicrosystems
This little guy is no neon sign illuminated jellyfish but a larvae of Terebratalia transversa imaged with Multiphoton technology. While the larvae is drifting in the ocean among the plankton, the adult animal is attached to the sea ground protected by two valves. Sample courtesy of Prof. Andreas Wanninger, Vienna, Austria. Learn more about Multiphoton: http://bit.ly/2hMLYyY #fromeyetoinsight #microscopy #imaging #resolution #multiphoton #confocal #microscope #microscopy #terebrataliatransversa #research #science #scienceiscool #biology #leica #leicamicrosystems
Deep Tissue Imaging with the Leica TCS SP8 MP Multiphoton Microscope: Ureteric bud from an embryonic day 16 kidney from a HoxB7 EGFP mouse. Courtesy of Deborah Hyink, Mount Sinai School of Medicine, New York, NY, USA #fromeyetoinsight #microscope #microscopy #deeptissue #biology #mouse #kidney #nature #lifescience #multiphoton #2photon #twophotonmicroscopy #mountsinai #research #imaging #developmental #leicamicrosystems
Multiphoton image of the retina of a Drosophila eye. Drosophila melanogaster is also known as the common fruit fly or vinegar fly. ID is a widely used model organism for biomedical research. With multiphoton microscopy we can image several hundreds of micrometers deep into biological samples. Learn more about our latest technology in this field: http://bit.ly/2aeE1lF #fromeyetoinsight #leicamicrosystems #eyes #retina #fly #microscopy #microscope #drosophila #multiphoton #confocal #science #biology #nature #natureisbeautiful #research #colorful #awesome #micro #fruitfly #tiny
multiphoton image of a mouse diaphragm. The diaphragm is a thin structure of muscle and fibrous tissue that separates the thoracic cavity from the abdomen. What is interesting here: you can see how muscles and neuros are connected Green: nerve fibers, red: myosin in muscle fibers. #fromeyetoinsight #microscopy #microscope #multiphoton #leicamicrosystems #biology #science #lifescience #natureisbeautiful #scienceiscool #colorful #research #mouse #muscle #neuron #synapse #myosin #cell #micro