29 Posts

brainsurgerydropout #BrainMetastasis This is a composite image of a #brain section with multiple #metastatic #breastcancer colonies (green; blood vessels are red). You can see distinct patterns of growth because cancer is heterogeneous (made up of genetically-distinct cells). My first #postdoc work identified the receptor metastatic cancer cells use to establish and grow in the brain. It turns out this receptor is critical for growth and progression of many aggressive solid cancers including #glioblastoma. This is the receptor we are now targeting with our first drug candidate... We feel it will be a game changer. @fashionsurgeon and I are working hard to bring this to #clinicaltrials! 🔬 PS: the scale bar is 1mm. #science #microscopy #leica #confocal #multiphoton #immunohistochemistry #gfp #neurosurgery #surgery #medschool #premed #laboratory #oncology #breastcancer #orphandrug #biotechnology #startup #startuplife #startupgrind 3mon

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Normal Spectra-Physics
spectraphysics New Image Gallery for #multiphoton multimodal bio-imaging: DM us to contribute your images http://ow.ly/SlLpF 4mon

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olympuslifescience The labeling technique presented here has the playful name, "brainbow." Using this process, individual brain neurons are labeled with different colors, allowing researchers to easily distinguish them from one another.

Credit: Pierre Mahou

#olympus #bioscapes #multiphoton #3D #video #neuron #bioscience #biology #bird #birds #brainbow #neurology #neuroscience #neurons #microscopy #microscope #microscopic #micro #microscopes #nature #science #research #optics #imaging #objective #cell #cells #🔬
5mon

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brainsurgerydropout #Timelapse imaging of active blood flow in #brain capillaries of the cortex imaged with #multiphoton #microscopy. The blood was imaged with intravascular dye therefore the black voids and streaks represent shadows of single red blood cells trafficking through the capillaries. These shadows can be used to calculate velocity in individual capillary segments with calculus (see, it is useful for something! ). Images are taken 1 second apart. #vascularbiology #neuroscience #neurosurgery #laboratory #microscopy #medicine #science #cancer #research #biophysics #biotechnology #startup 5mon
  •   cayleighbrown Wow!!! 5mon
  •   7th_individuality What dye was it? 5mon
  •   brainsurgerydropout @7th_individuality It wasn't actually a "dye" per se... we used a FITC-dextran with high enough molecular weight that it stays in the intravascular compartment for several hours. Great question. 5mon
  •   7th_individuality Thanks for your prompt response. I didn't know about FITC-dextran staying in for long hours. What is that you're working on? This is so cool by the way. Do you use any neuroscience computations? 5mon
  •   brainsurgerydropout @7th_individuality This was from my first postdoc actually. We were looking to study single cell metastasis in the brain. While generally proficient at maths, I usually outsource it. 5mon
  •   7th_individuality Awesome. 5mon

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Normal Startup Founder & Cancer KILLA
brainsurgerydropout #FGF One of my favorite images from #Oxford where I spent 50% of my life in the dark of the microscope room. I spent so much time in there the only other country I visited in 3 years was Ireland, haha. #ScienceWins This is a 2D depth projection image of a growing triple negative #BreastCancer #metastasis in the brain... violet cells are towards the top of the pile, red at the bottom. #fuckglioblastomafriday #fuckcancer #cancerresearch #medicine #laboratory #science #oncology #multiphoton #microscopy #brainbow #neuroscience #startup #sciart #biotechnology 6mon

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olympuslifescience This capture shows immune cells in action, actively defending a mouse against infection. This sample was created using intravital #microscopy.

Credit: Dr. Thorsten Mempel
#multiphoton #olympus #bioscapes #fluorescent #fluorescence #color #colorful #cells #cellbiology #biology #rodent #science #research #pathology #intravital #video #mouse #optics #objective #micro #microscopic #microscopy #microscopes #🔬
7mon
  •   microstuff Great chase! Haha. Fantastic! 7mon
  •   ah.ha0098 Fantastic!there r three kind of color,which one is what? 7mon
  •   farnaz_kia breathtaking power of god 7mon
  •   olympuslifescience @hannah.linton @ah.ha0098 This recording shows cytotoxic T cell-interaction with Ag-pulsed B cells in the lymph node of a mouse. B cells are stained ex vivo with the blue fluorescent DNA dye Hoechst 33342 to label the nucleus and the red fluorescent dye Celltracker Orange to label cellular proteins. B cells are pulsed with a surface antigen that is recognized by the EGFP-expressing cytotoxic T lymphocytes (green). 7mon
  •   hannah.linton Amazing, thanks for the clarification 7mon
  •   sarahluvspink @iliekpiee pink!! I like 6mon

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Normal Spectra-Physics
spectraphysics New article: Compact fixed wavelength #femtosecond #Lasers for #Multiphoton #Imaging #SPIE http://ow.ly/NWdqn 7mon

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Normal Spectra-Physics
spectraphysics New article:#Multiphoton #Imaging w/high-peak-power #Laser -- see more@LASER_Munich A2.307 ow.ly/NWcwD 8mon

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manateejohn Making sure people are clear on the concept #multiphoton #confocal #microscopy #laser 1y

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cellpress #NationalStemCellAwarenessDay
Not Born this Way

By Thomas Deerinck, NCMIR, #UCSD

For decades researchers thought that the production of #neurons stopped early in life, leaving the adult #brain with a finite number of neurons. The discovery of #neural #stemcells with #selfrenewing capacity and multi-potency has radically changed this view, and it is now well accepted that the birth of new neurons continues throughout adulthood. Adult neurogenesis occurs in two primary locations: the #olfactory #bulb and the central part of the #hippocampus, called the #dendate #gyrus (shown at the left). Image: Widefield #multiphoton #fluorescence image of a rat hippocampus stained to reveal the distribution of #glia (cyan), #neurofilaments (green) and #cell #nuclei (yellow). The image was produced as part of an ongoing brain mapping project for the Whole Brain Catalog. Wholebraincatalog.org

#CellPictureShow #ISSCR #neuroscience #Neuron #neuro #neurology #sciart
1y
  •   amoonia_ This is so freaking COOL!!! 1y
  •   _sempreguica Amazing!! The exercise increase the BDNF in hippocampus. So is Very important for neurogenesis ;)! 1y
  •   w_k_o Nice! 1y
  •   cellpress Thanks so much all! willcamaral next July we are having a #CellSymposium on Exercise Metabolism! Very excited for it- one of our sessions will cover benefits for the brain. 1y
  •   cellpress @willcamaral meant to tag you to comment above! 1y
  •   cellpress #uss r 1y
  •   hiangela @cellpress I'm an undergrad biology major and I love that you guys have Instagram! 1y
  •   cellpress @angeliuu glad to hear that, we'll definitely keep posting. thanks for the follow! 1y

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cellpress To kick off National #StemCell Awareness Day, we’ll be posting some of our most gorgeous stem cell images all day!
#Intestinal #StemCells
By Paul Appleton, University of Dundee

The #epithelium of the small #intestine is the fastest #selfrenewing tissue in #mammals. At the bottom of each #villus is a narrow tubular #structure, called the #crypt (orange), where multi-potent stem cells reside. These #cells divide daily, sending #progeny up the crypt and the villus to replace the cells continuously sloughed away by passing food.

Image: 3D rendering of crypts in a mouse small intestine. The crypt lumen (orange) are surrounded by #epithelial cells (blue). Image acquired with a #Biorad Radiance 2100MP #multiphoton #microscope based on #Nikon Eclipse TE2000-U inverted microscope. Multi-#photon #excitation provided by a Coherent #Chameleon Titanium #Sapphire #laser at 790nm. #Nuclei are stained blue with #DAPI, and F-actin is stained orange with rhodamine phalloidin.
1y

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zeiss_microscopy Multiphoton microscopy of mouse motor neurons Motor neurons in the sternomastoid muscle of a postnatal day 9 mouse which constitutively express cytoplasmic CFP and YFP in varying proportions under the thy1 promoter. Acetylcholine receptors are labeled with alpha-bungarotoxin-Alexa-647. Imaged with ZEISS LSM 780 NLO. Courtesy of Stephen Turney, MCB, Harvard University, USA 1y

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cellpress #CellPressPictureShow Image:
Beyond the #Embryo
By Thomas Deerinck, NCMIR, #UCSD

Even after #development stops, tissues still need regular maintenance. This is the job of "adult #stemcells." These #cells sit quietly in the nooks and crannies of #organs, waiting for the signal to start dividing and #differentiating.

#Mouse #intestine section imagined with #widefield #multiphoton #microscopy. #Actin (green) and #lamin (red) are immunolabeled with #quantum dots (QD 525 and QD 655, respectively); #nuclei in blue.

#sciart #stemcell #biology #science #Zeiss #CellPress #CellPressPictureShow
1y

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zeiss_microscopy Mouse Mesentery Tissue Multiphoton Imaging; Green: Signal from Pecam showing the lymphatic vessel and SHG signal of Collagen, Red: mOrange, expressed by endothelial cells. Specimen courtesy of F. Kiefer, MPI for Molecular Biomedicine, Münster, Germany. 2y

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