14 Posts

manateejohn Making sure people are clear on the concept #multiphoton #confocal #microscopy #laser 21h

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cellpress #NationalStemCellAwarenessDay
Not Born this Way

By Thomas Deerinck, NCMIR, #UCSD

For decades researchers thought that the production of #neurons stopped early in life, leaving the adult #brain with a finite number of neurons. The discovery of #neural #stemcells with #selfrenewing capacity and multi-potency has radically changed this view, and it is now well accepted that the birth of new neurons continues throughout adulthood. Adult neurogenesis occurs in two primary locations: the #olfactory #bulb and the central part of the #hippocampus, called the #dendate #gyrus (shown at the left). Image: Widefield #multiphoton #fluorescence image of a rat hippocampus stained to reveal the distribution of #glia (cyan), #neurofilaments (green) and #cell #nuclei (yellow). The image was produced as part of an ongoing brain mapping project for the Whole Brain Catalog. Wholebraincatalog.org

#CellPictureShow #ISSCR #neuroscience #Neuron #neuro #neurology #sciart
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  •   amoonia_ This is so freaking COOL!!! 3w
  •   willcamaral Amazing!! The exercise increase the BDNF in hippocampus. So is Very important for neurogenesis ;)! 3w
  •   w_k_o Nice! 3w
  •   cellpress Thanks so much all! willcamaral next July we are having a #CellSymposium on Exercise Metabolism! Very excited for it- one of our sessions will cover benefits for the brain. 3w
  •   cellpress @willcamaral meant to tag you to comment above! 3w
  •   cellpress #uss r 3w
  •   angeliuu @cellpress I'm an undergrad biology major and I love that you guys have Instagram! 3w
  •   cellpress @angeliuu glad to hear that, we'll definitely keep posting. thanks for the follow! 3w

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cellpress To kick off National #StemCell Awareness Day, we’ll be posting some of our most gorgeous stem cell images all day!
#Intestinal #StemCells
By Paul Appleton, University of Dundee

The #epithelium of the small #intestine is the fastest #selfrenewing tissue in #mammals. At the bottom of each #villus is a narrow tubular #structure, called the #crypt (orange), where multi-potent stem cells reside. These #cells divide daily, sending #progeny up the crypt and the villus to replace the cells continuously sloughed away by passing food.

Image: 3D rendering of crypts in a mouse small intestine. The crypt lumen (orange) are surrounded by #epithelial cells (blue). Image acquired with a #Biorad Radiance 2100MP #multiphoton #microscope based on #Nikon Eclipse TE2000-U inverted microscope. Multi-#photon #excitation provided by a Coherent #Chameleon Titanium #Sapphire #laser at 790nm. #Nuclei are stained blue with #DAPI, and F-actin is stained orange with rhodamine phalloidin.
3w

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Normal ZEISS Microscopy
zeiss_microscopy Multiphoton microscopy of mouse motor neurons Motor neurons in the sternomastoid muscle of a postnatal day 9 mouse which constitutively express cytoplasmic CFP and YFP in varying proportions under the thy1 promoter. Acetylcholine receptors are labeled with alpha-bungarotoxin-Alexa-647. Imaged with ZEISS LSM 780 NLO. Courtesy of Stephen Turney, MCB, Harvard University, USA 1mon

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cellpress #CellPressPictureShow Image:
Beyond the #Embryo
By Thomas Deerinck, NCMIR, #UCSD

Even after #development stops, tissues still need regular maintenance. This is the job of "adult #stemcells." These #cells sit quietly in the nooks and crannies of #organs, waiting for the signal to start dividing and #differentiating.

#Mouse #intestine section imagined with #widefield #multiphoton #microscopy. #Actin (green) and #lamin (red) are immunolabeled with #quantum dots (QD 525 and QD 655, respectively); #nuclei in blue.

#sciart #stemcell #biology #science #Zeiss #CellPress #CellPressPictureShow
2mon

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Normal ZEISS Microscopy
zeiss_microscopy Mouse Mesentery Tissue Multiphoton Imaging; Green: Signal from Pecam showing the lymphatic vessel and SHG signal of Collagen, Red: mOrange, expressed by endothelial cells. Specimen courtesy of F. Kiefer, MPI for Molecular Biomedicine, Münster, Germany. 4mon

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